@article{MikolaschHahn2021, author = {Annett Mikolasch and Veronika Hahn}, title = {Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures}, series = {Microorganisms}, volume = {9}, number = {11}, editor = {Annett Mikolasch and Mariam Gaid}, publisher = {MDPI}, issn = {2076-2607}, doi = {10.3390/microorganisms9112199}, url = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-57218}, year = {2021}, abstract = {Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.}, language = {en} }