TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Goltz, Annemarie
A1  - Janowitz, Deborah
A1  - Hannemann, Anke
A1  - Nauck, Matthias
A1  - Hoffmann, Johanna
A1  - Seyfart, Tom
A1  - Völzke, Henry
A1  - Terock, Jan
A1  - Grabe, Hans Jörgen
T1  - Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study
JF  - Neuropsychobiology
N2  - Background: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. Methods: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926). The associations of serum BDNF and vitamin D levels with depressive symptoms (measured using the Patient Health Questionnaire) were assessed with binary and multinomial logistic regression models. The associations of serum BDNF and vitamin D levels with obesity (measured by the waist-to-hip ratio [WHR]) were assessed with binary logistic and linear regression models with restricted cubic splines. Results: Logistic regression models revealed inverse associations of vitamin D with depression (OR = 0.966; 95% CI 0.951–0.981) and obesity (OR = 0.976; 95% CI 0.967–0.985). No linear association of serum BDNF with depression or obesity was found. However, linear regression models revealed a U-shaped association of BDNF with WHR (p < 0.001). Conclusion: Vitamin D was inversely associated with depression and obesity. BDNF was associated with abdominal obesity, but not with depression. At the population level, our results support the relevant roles of vitamin D and BDNF in mental and physical health-related outcomes.
KW  - -
KW  - Brain-derived neurotrophic factor
KW  - Vitamin D
KW  - Depression
KW  - Obesity
Y1  - 2018
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-32938
SN  - 0302-282X
SS  - 0302-282X
SN  - 1423-0224
SS  - 1423-0224
U6  - https://doi.org/10.1159/000489864
DO  - https://doi.org/10.1159/000489864
PM  - 29920493
VL  - 76
IS  - 4
SP  - 171
EP  - 181
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -