TY - JOUR
U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1 - Ittermann, Till
A1 - Lorbeer, Roberto
A1 - Tiller, Daniel
A1 - Lehmphul, Ina
A1 - Kluttig, Alexander
A1 - Felix, Stephan B.
A1 - Werdan, Karl
A1 - Greiser, Karin Halina
A1 - Köhrle, Josef
A1 - Völzke, Henry
A1 - Dörr, Marcus
T1 - Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies
JF - European Thyroid Journal
N2 - Background: There is only limited data on the potential association between thyroid dysfunction and peripheral arterial disease (PAD). Objective: The aim of our study was to investigate the potential association of thyroid function, as defined by serum concentrations of the clinically used primary thyroid function marker thyrotropin [i.e. thyroid-stimulating hormone (TSH)] and 3,5-diiodothyronine (3,5-T2), with the ankle-brachial index (ABI) as a marker of PAD. Methods: We used data from 5,818 individuals from three cross-sectional population-based studies conducted in Northeast (SHIP-2 and SHIP-TREND) and Central Germany (CARLA). Measurement of serum TSH concentrations was conducted in one central laboratory for all three studies. In a randomly selected subpopulation of 750 individuals of SHIP-TREND, serum 3,5-T2 concentrations were measured with a recently developed immunoassay. ABI was measured either by a hand-held Doppler ultrasound using the Huntleigh Dopplex D900 or palpatorily by the OMRON HEM-705CP device. Results: Serum TSH concentrations were not significantly associated with ABI values in any of the three studies. Likewise, groups of individuals with a TSH <0.3 mIU/l or with a TSH ≥3.0 mIU/l had no significantly different ABI values in comparison with individuals with a TSH in the reference range. Analyses regarding TSH within the reference range or serum 3,5-T2 concentrations did not reveal consistent significant associations with the ABI. No sex-specific associations were detected. Conclusions: The results of our study do not substantiate evidence for an association between thyroid function and PAD, but further studies are needed to investigate the associations of overt forms of thyroid dysfunction with PAD.
KW - -
KW - Epidemiology
KW - Population-based study
KW - Thyrotropin
KW - Thyroid
KW - Peripheral arterial disease
KW - Ankle-brachial index
UN - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31261
UR - www.karger.com/etj
SN - 2235-0640
SS - 2235-0640
SN - 2235-0802
SS - 2235-0802
U6 - https://doi.org/10.1159/000381309
DO - https://doi.org/10.1159/000381309
PM - 26601080
VL - 4
IS - Suppl 1
SP - 101
EP - 107
PB - S. Karger AG
CY - Basel, Switzerland
ER -