@article{MaternKochPetersmannetal.2020,
  author    = {Johannes Matern and Raphael Koch and Astrid Petersmann and Thomas Kocher and Peter Eickholz and Katrin Lorenz and Ti‐Sun Kim and J{\"o}rg Meyle and Doğan Kaner and Ulrich Schlagenhauf and Martina Gravemeier and Inga Harks and Benjamin Ehmke},
  title     = {Effect of periodontal therapy on adipokine biomarkers in overweight},
  series   = {Journal of Clinical Periodontology},
  volume    = {47},
  number    = {7},
  doi       = {10.1111/jcpe.13288},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-40875},
  pages     = {842 -- 850},
  year      = {2020},
  abstract  = {Abstract Aim The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m2) or moderate (21–24 kg/m2) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients.},
  language  = {en}
}