@phdthesis{Trentin2018, author = {Ivan Trentin}, title = {Molybdopterin-Modeling: The Synthesis of Pterin Dithiolene Ligands}, journal = {Molybdopterin-Modelling: Synthese von Pterin Dithiolen Liganden}, url = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-27451}, pages = {139}, year = {2018}, abstract = {The synthesis of pterin-dithiolene ligands was achieved by employing the radical nucleophilic substitution, i.e. the so-called “Minisci- Reaction”1. This protocol was used for the first time by Professor W. Pfleiderer on pterin substrates2 and proved a powerful method for the preparation of 6 acyl-pterins in course of this work. Subsequent construction of the dithiolene ring facilitates the synthesis of pterin-dithiolene ligands with completely unprotected pterin moieti. The molybdenum cofactor is probably one of the most relevant discoveries in the recent history of pterin chemistry and biochemistry. Many efforts have been made for the preparation of compounds able to mimic the features of the Moco ligand system called \"Molybdopterin\". In fact, the study of MPT models enables a deeper understanding of the “mechanism of function” of this cofactor and most importantly, lays the foundation for a potential treatment for the Moco related diseases MoCOD and iSOD.}, language = {en} }