TY  - THES
U1  - Dissertation / Habilitation
A1  - Zorn, Katja
T1  - Development and application of fungal lipases in lipid modification
N2  - Oils and fats from natural origin are sustainable sources for a broad range of economically relevant products in food, feed, fuel, oleochemical, and cosmetic industries. Thereby, a huge variety of lipids or lipid-derived products exist which distinguish themselves by their unique physical properties making them suitable for their individual applications. To obtain such functional lipids in an environmentally friendly manner, enzymes can be employed. In that context, lipases have been proven to be valuable biocatalysts in lipid modification, which are broadly applied in industry. Even though they have been implemented successfully in the dairy, baking, and detergent industries, there is an increasing demand for the expansion of their utilization. New technologies like protein engineering and the implementation of process development are employed in solving this task. Within the enzymes in lipid modification, lipases are the most applied catalysts and in this thesis their utilization was expanded successfully to the implementation of novel separation processes and the production of improved drug delivery matrices.
N2  - Enzyme für die Lipidmodifizierung ermöglichen die Entwicklung  von nachhaltigeren und häufig effizienteren Prozessen und werden daher in großem Umfang unter anderem bei der Herstellung von oleochemischen Stoffen, gesunden Fetten und Ölen sowie Biokraftstoffen eingesetzt. Dabei bietet das Protein Engineering die Möglichkeit um den Einsatz von Enzymen zu erweitern und sie auf die Prozessanforderungen abzustimmen. Innerhalb der Enzyme in der Lipidmodifizierung sind Lipasen, die am häufigsten verwendeten Katalysatoren, und in dieser Arbeit wurde ihre Verwendung erfolgreich auf die Implementierung neuer Trennverfahren und die Herstellung verbesserter Arzneimittelabgabematrizen erweitert.
KW  - Lipase
KW  - Protein Engineering
KW  - Lipid Modification
KW  - Biocatalysis
KW  - CAL-A
KW  - Lipase
KW  - Protein Engineering
KW  - Lipid Modification
KW  - Biocatalysis
KW  - CAL-A
Y2  - 2019
U6  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30125
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30125
SP  - 137
S1  - 137
ER  -