@phdthesis{Mekonnen2019,
  author    = {Solomon Abera Mekonnen},
  title     = {On the missing links between the epidemiology and pathophysiology of Staphylococcus aureus},
  journal    = {{\"U}ber die fehlenden Verbindungen zwischen Epidemiologie und Pathophysiologie von Staphylococcus aureus},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-28332},
  pages     = {138},
  year      = {2019},
  abstract  = {The bacterium Staphylococcus aureus is a notorious pathogen that causes dangerous and difficult-to-treat infections. This applies especially to methicillin-resistant S. aureus, better known as MRSA. MRSA infections were originally associated with healthcare settings as a consequence of clinical antibiotic therapy. However, in recent years MRSA infections have become more common among healthy individuals in the community. The community-associated (CA-)MRSA lineages are generally more aggressive than hospital-associated (HA-) lineages. Therefore, it is alarming that such CA-MRSA lineages are now emerging in hospitals. This raises the fundamental question of how CA-MRSA adapts to this new niche. Further, since the originally distinguishing features of CA- and HA-MRSA are losing discriminative value, it is important from a healthcare perspective to identify novel distinctive markers for early recognition and elimination of hospital-adapted CA-MRSA. In the present PhD research, these challenges were tackled with a ‘multi-omics’ approach focused on the USA300 lineage of MRSA, originally identified as CA, but now also causing hospital outbreaks. The results show that hospital-adapted USA300 isolates produce an altered spectrum of virulence factors, changed their metabolism, and exploit human immune cells as a protective environment against antibiotics. Importantly, hospital-adapted CA-MRSA strains can be recognized through distinctive patterns of gene expression and secreted virulence factors. Altogether, these observations show that the epidemic behaviour of MRSA is a multi-factorial trait, and they provide new insights into the missing links between epidemiology and pathophysiology of S. aureus. Moreover, they highlight the benefits of multi-omics technologies for protecting patients and frail individuals against the aggressive CA-MRSA.},
  language  = {en}
}