TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Normann, Nicole
A1  - Tietz, G.
A1  - Kühn, Andrew W.
A1  - Fuchs, Christian
A1  - Balau, Veronika
A1  - Schulz, Katja
A1  - Kolata, Julia
A1  - Schuerholz, Tobias
A1  - Petersmann, Astrid
A1  - Stentzel, S.
A1  - Steil, Leif
A1  - Kuhn, Sven Olaf
A1  - Meissner, Karin
A1  - Völker, Uwe
A1  - Nauck, Matthias
A1  - Steinmetz, Ivo
A1  - Raafat, Dina
A1  - Gründling, Matthias
A1  - Bröker, Barbara M.
T1  - PATHOGEN-SPECIFIC ANTIBODY PROFILES IN PATIENTS WITH SEVERE SYSTEMIC INFECTIONS
JF  - Eur Cells & Mater.
N2  - Infections are often caused by pathobionts, endogenous bacteria that belong to the microbiota. Trauma and surgical intervention can allow bacteria to overcome host defences, ultimately leading to sepsis if left untreated. One of the main defence strategies of the immune system is the production of highly specific antibodies. In the present proof-of-concept study, plasma antibodies against 9 major pathogens were measured in sepsis patients, as an example of severe systemic infections. The binding of plasma antibodies to bacterial extracellular proteins was quantified using a semi-automated immunoblot assay. Comparison of the pathogen-specific antibody levels before and after infection showed an increase in plasma IgG in 20 out of 37 tested patients. This host-directed approach extended the results of pathogen-oriented microbiological and PCR diagnostics: a specific antibody response to additional bacteria was frequently observed, indicating unrecognised poly-microbial invasion. This might explain some cases of failed, seemingly targeted antibiotic treatment.
KW  - Systemic infection
KW  - sepsis
KW  - pathogen-specific IgG
KW  - serology
KW  - antibody response
Y1  - 2020
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-44474
SN  - 1473-2262
SS  - 1473-2262
U6  - https://doi.org/htpp:/10.22203/eCM.v039a11
DO  - https://doi.org/htpp:/10.22203/eCM.v039a11
VL  - 39
SP  - 171
EP  - 182
PB  - AO Research Institute Davos
CY  - Aberystwyth, Wales
ER  -