@phdthesis{Herbst2017,
  author    = {Diana Herbst},
  title     = {Wirkung von Simvastatin und Bezafibrat auf die Gef{\"a}{\"s}kontraktilit{\"a}t in vitro - eine experimentelle Studie},
  journal    = {Effect of Simvastatin and Bezafibrate on vascular contractility in vitro - an experimental study},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-21004},
  pages     = {84},
  year      = {2017},
  abstract  = {Lipid-lowering medications are used in the therapy of dyslipidemia. The goal of the experiments was not to analyze their lipid-lowering effects. It was to explore the influence of simvastatin and bezafibrate on vascular smooth muscle. With this hypothesis a tension shift of vascular smooth muscle due to simvastatin and bezafibrate is supposed. This assumption was pursued with experimental animal studies. Examining aortic rings from rat aorta using isotonic myotonomerty in vitro, the influence of simvastatin and bezafibrate on smooth muscle tension can be demonstrated. In order to determine the exact underlying mechanism which will trigger a tension shift, various receptor blockers are given during relaxation experiments with precontraction. In contraction experiments potassium chloride is added cumulatively after incubation with simvastatin or bezafibrate. The results are displayed in a nonlinear regression curve using the negative decimal logarithm for the determined half maximal effects. Simvastatin and bezafibrate produce a significant relaxation during precontraction with 20 millimoles potassium chloride to the aortic smooth muscle without endothelium. In other experiments with simvastatin and bezafibrate with precontraction with or without blocking receptors, no significant relaxations are seen. If soluble guanylate cyclase (solGC), adenylate cyclase (AC) and calcium-activated potassium channels (KCa) are inhibited, a not significant increased tension at the highest concentration of simvastatin is seen. Contraction experiments with potassium chloride and simvastatin indicate no significant differences in sensitivity.},
  language  = {de}
}