@phdthesis{Merkle2020,
  author    = {Lena-Maria Merkle},
  title     = {Populationsbasierte Untersuchung des Bulbus und Sulcus olfactorius hinsichtlich Stirn- und Kieferh{\"o}hlenverschattungen – Validierung eines MRT-Protokolls},
  journal    = {Epidemiologic study regarding influencing factors on olfactory bulb volume and sulcus depth},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-40673},
  pages     = {98},
  year      = {2020},
  abstract  = {Background: Smell dysfunctions have a large prevalence of 18 – 19 \% and are early symptoms of sinonasal and further diseases. The volume of the olfactory bulb (OBV) is an indicator of the olfactory function. Nevertheless, information about normal OBV and olfactory sulcus depth (OSD) in human populations are still missing. In this study, a standardized messing procedure is presented and validated. Furthermore, norm values for OBV and OSD are published and it was investigated, whether there exists any correlation between OBV or OSD and the existence of shadows in the maxillary or frontal sinus as a surrogate for sinonasal diseases. Methodology / Principal: In 212 MRT´s, the olfactory bulb was constituted and measured by planimetric contouring in all coronar planes. The OSD was measured in the posterior tangent through the eyeballs. Intra- and interrater reliability was proved due to repeated measurements. Results: The mean OBV was 104,6 mm³ (SD = 44,9 mm³) and the mean OSD was 8,39 mm (SD = 1,71 mm). The interrater reliability of OSD was excellent (ICC= 0,79 – 0,89), whereas the measurements of the OBV consumed lots of time and ICC was 0,46 – 0,64. There was no significant correlation between OSD or OBV and the existence of shadows in the maxillary or frontal sinus. There correlation between the OSD and gender and age was significant. Conclusions: Measurements of the OSD were reliable and practicable whereas for the measurement of the OBV a semiautomatical method is recommended. For further studies, duration of clinical symptoms should be included when nasal sinus are considered.},
  language  = {de}
}