TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Bekeschus, Sander
A1  - Meyer, Dorothee
A1  - Arlt, Kevin
A1  - von Woedtke, Thomas
A1  - Miebach, Lea
A1  - Freund, Eric
A1  - Clemen, Ramona
T1  - Argon Plasma Exposure Augments Costimulatory Ligands and Cytokine Release in Human Monocyte-Derived Dendritic Cells
JF  - International Journal of Molecular Sciences
N2  - Cold physical plasma is a partially ionized gas expelling many reactive oxygen and nitrogen
species (ROS/RNS). Several plasma devices have been licensed for medical use in dermatology, and
recent experimental studies suggest their putative role in cancer treatment. In cancer therapies with
an immunological dimension, successful antigen presentation and inflammation modulation is a
key hallmark to elicit antitumor immunity. Dendritic cells (DCs) are critical for this task. However,
the inflammatory consequences of DCs following plasma exposure are unknown. To this end,
human monocyte-derived DCs (moDCs) were expanded from isolated human primary monocytes;
exposed to plasma; and their metabolic activity, surface marker expression, and cytokine profiles
were analyzed. As controls, hydrogen peroxide, hypochlorous acid, and peroxynitrite were used.
Among all types of ROS/RNS-mediated treatments, plasma exposure exerted the most notable
increase of activation markers at 24 h such as CD25, CD40, and CD83 known to be crucial for T cell
costimulation. Moreover, the treatments increased interleukin (IL)-1α, IL-6, and IL-23. Altogether,
this study suggests plasma treatment augmenting costimulatory ligand and cytokine expression in
human moDCs, which might exert beneficial effects in the tumor microenvironment.
KW  - -
KW  - CAP
KW  - cancer
KW  - cold atmospheric pressure plasma
KW  - hydrogen peroxide
KW  - hypochlorous acid
KW  - moDCs
KW  - peroxynitrite
KW  - reactive oxygen and nitrogen species
KW  - RNS
KW  - ROS
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-65222
SN  - 1422-0067
SS  - 1422-0067
U6  - https://doi.org/10.3390/ijms22073790
DO  - https://doi.org/10.3390/ijms22073790
VL  - 22
IS  - 7
SP  - 14
S1  - 14
PB  - MDPI
CY  - Basel
ER  -