TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Ohlinger, Ralf
A1  - Stomps, Andrea
A1  - Paepke, Stefan
A1  - Blohmer, Jens-Uwe
A1  - Grunwald, Susanne
A1  - Hahndorf, Wenke
A1  - Camara, Oumar
A1  - Deichert, Ulrich
A1  - Peisker, Uwe
A1  - Kohlmann, Thomas
A1  - Buchholz, Ines
A1  - Hegenscheid, Katrin
A1  - Utpatel, Kirsten
A1  - Zygmunt, Marek
A1  - Hahn, Markus
T1  - Ductoscopic Detection of Intraductal Lesions in Cases of Pathologic Nipple Discharge in Comparison with Standard Diagnostics: The German Multicenter Study
JF  - Oncology Research and Treatment
N2  - SummaryBackground: According to the literature, ductoscopy is gaining increasing importance in the diagnosis of intraductal anomalies in cases of pathologic nipple discharge. In a multicenter study, the impact of this method was assessed in comparison with that of standard diagnostics. Patients and Methods: Between 09/2006 and 05/2009, a total of 214 patients from 7 German breast centers were included. All patients underwent elective ductoscopy and subsequent ductal excision because of pathologic nipple discharge. Ductoscopy was compared with the following standard diagnostics: breast sonography, mammography, magnetic resonance imaging (MRI), galactography, cytologic nipple swab, and ductal lavage cytology. The histological and imaging results were compared and contrasted to the results obtained from the nipple swab and cytologic assessment. Results: Sonography had the highest (82.9%) sensitivity, followed by MRI (82.5%), galactography (81.3%), ductoscopy (71.2%), lavage cytology (57.8%), mammography (57.1%), and nipple swab (22.8%). Nipple swabs had the highest (85.5%) specificity, followed by lavage cytology (85.2%), ductoscopy (49.4%), galactography (44.4%), mammography (33.3%), sonography (17.9%), and MRI (11.8%). Conclusion: Currently, ductoscopy provides a direct intraoperative visualization of intraductal lesions. Sensitivity and specificity are similar to those of standard diagnostics. The technique supports selective duct excision, in contrast to the unselective technique according to Urban. Therefore, ductoscopy extends the interventional/diagnostic armamentarium.
KW  - -
KW  - Nipple discharge
KW  - Endoscopic breast ductoscopy
KW  - Breast cancer
KW  - Intraductal lesion
Y1  - 2014
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-32349
SN  - 2296-5270
SS  - 2296-5270
SN  - 2296-5262
SS  - 2296-5262
U6  - https://doi.org/10.1159/000368338
DO  - https://doi.org/10.1159/000368338
PM  - 25427580
VL  - 37
IS  - 11
SP  - 628
EP  - 632
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -