TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Guertler, Diana
A1  - Moehring, Anne
A1  - Krause, Kristian
A1  - Batra, Anil
A1  - Eck, Sandra
A1  - Freyer-Adam, Jennis
A1  - Ulbricht, Sabina
A1  - Rumpf, Hans-Jürgen
A1  - Bischof, Gallus
A1  - John, Ulrich
A1  - Meyer, Christian
T1  - Copattern of depression and alcohol use in medical care patients: cross- sectional study in Germany
JF  - BMJ Open
N2  - Objective 
To predict depressive symptom severity and presence of major depression along the full alcohol use continuum.

Design 
Cross-sectional study.

Setting
Ambulatory practices and general hospitals from three sites in Germany.

Participants
Consecutive patients aged 18–64 years were proactively approached for an anonymous health screening (participation rate=87%, N=12 828). Four continuous alcohol use measures were derived from an expanded Alcohol Use Disorder Identification Test (AUDIT): alcohol consumption in grams per day and occasion, excessive consumption in days per months and the AUDIT sum score. Depressive symptoms were assessed for the worst 2-week period in the last 12 months using the Patient Health Questionnaire (PHQ-8). Negative binomial and logistic regression analyses were used to predict depressive symptom severity (PHQ-8 sum score) and presence of major depression (PHQ-8 sum score≥10) by the alcohol use measures.

Results 
Analyses revealed that depressive symptom severity and presence of major depression were significantly predicted by all alcohol use measures after controlling for sociodemographics and health behaviours (p<0.05). The relationships were curvilinear: lowest depressive symptom severity and odds of major depression were found for alcohol consumptions of 1.1 g/day, 10.5 g/occasion, 1 excessive consumption day/month, and those with an AUDIT score of 2. Higher depressive symptom severity and odds of major depression were found for both abstinence from and higher levels of alcohol consumption. Interaction analyses revealed steeper risk increases in women and younger individuals for most alcohol use measures.

Conclusion 
Findings indicate that alcohol use and depression in medical care patients are associated in a curvilinear manner and that moderation by gender and age is present.
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-43764
SN  - 2044-6055
SS  - 2044-6055
U6  - https://doi.org/10.1136/bmjopen-2019-032826
DO  - https://doi.org/10.1136/bmjopen-2019-032826
VL  - 10
IS  - 5
SP  - 9
S1  - 9
PB  - BMJ Publishing Group
CY  - London
ER  -