@article{SchneidewindNeumannKnolletal.2017,
  author    = {Laila Schneidewind and Thomas Neumann and Florian Knoll and Kathrin Zimmermann and Sigrun Smola and Christian Andreas Schmidt and William Kr{\"u}ger},
  title     = {Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?},
  series   = {Acta Haematologica},
  volume    = {138},
  number    = {1},
  publisher = {S. Karger AG},
  address   = {Basel, Switzerland},
  issn      = {0001-5792},
  doi       = {10.1159/000468972},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31550},
  pages     = {3 -- 9},
  year      = {2017},
  abstract  = {Background: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. Methods: We conducted a retrospective study of 64 adult patients who received their first allogeneic stem cell transplantation between March 2010 and December 2014; the follow-up time was 2 years. Results: Acute leukemia was the most frequent underlying disease (45.3\%), and conditioning included myeloablative (67.2\%) and nonmyeloablative protocols (32.8\%). All patients received 10 mg of alemtuzumab on day -2 (20 mg in case of mismatch) as GvHD prophylaxis. Twenty-seven patients (41.5\%) developed cytomegalovirus (CMV) reactivation. BKPyV-associated hemorrhagic cystitis was diagnosed in 10 patients (15.6\%). Other opportunistic infections caused by viruses or protozoa occurred rarely (<10\%). There was no association of BKPyV or JCPyV with CMV reactivation, Epstein-Barr virus reactivation, human herpes virus 6, or parvovirus B19 infection requiring treatment. There was a significant correlation of BKPyV-associated hemorrhagic cystitis with toxoplasmosis (p = 0.013). Additionally, there was a significant link of simultaneous BKPyV and JCPyV viruria with toxoplasmosis (p = 0.047). BKPyV and JCPyV were not associated with GvHD, relapse, or death. Conclusion: We found no association of BKPyV or JCPyV with viral infections or GvHD. Only the correlation of both polyomaviruses with toxoplasmosis was significant. This is a novel and interesting finding.},
  language  = {en}
}