TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Schneidewind, Laila
A1  - Neumann, Thomas
A1  - Knoll, Florian
A1  - Zimmermann, Kathrin
A1  - Smola, Sigrun
A1  - Schmidt, Christian Andreas
A1  - Krüger, William
T1  - Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?
JF  - Acta Haematologica
N2  - Background: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. Methods: We conducted a retrospective study of 64 adult patients who received their first allogeneic stem cell transplantation between March 2010 and December 2014; the follow-up time was 2 years. Results: Acute leukemia was the most frequent underlying disease (45.3%), and conditioning included myeloablative (67.2%) and nonmyeloablative protocols (32.8%). All patients received 10 mg of alemtuzumab on day -2 (20 mg in case of mismatch) as GvHD prophylaxis. Twenty-seven patients (41.5%) developed cytomegalovirus (CMV) reactivation. BKPyV-associated hemorrhagic cystitis was diagnosed in 10 patients (15.6%). Other opportunistic infections caused by viruses or protozoa occurred rarely (<10%). There was no association of BKPyV or JCPyV with CMV reactivation, Epstein-Barr virus reactivation, human herpes virus 6, or parvovirus B19 infection requiring treatment. There was a significant correlation of BKPyV-associated hemorrhagic cystitis with toxoplasmosis (p = 0.013). Additionally, there was a significant link of simultaneous BKPyV and JCPyV viruria with toxoplasmosis (p = 0.047). BKPyV and JCPyV were not associated with GvHD, relapse, or death. Conclusion: We found no association of BKPyV or JCPyV with viral infections or GvHD. Only the correlation of both polyomaviruses with toxoplasmosis was significant. This is a novel and interesting finding.
KW  - -
KW  - Adult allogeneic stem cell transplantation
KW  - BK-associated hemorrhagic cystitis
KW  - BK polyomavirus
KW  - Graft-versus-host disease
KW  - Transplantation-associated infections
Y1  - 2017
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31550
SN  - 0001-5792
SS  - 0001-5792
SN  - 1421-9662
SS  - 1421-9662
U6  - https://doi.org/10.1159/000468972
DO  - https://doi.org/10.1159/000468972
PM  - 28591758
VL  - 138
IS  - 1
SP  - 3
EP  - 9
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -