@phdthesis{Decoutere2006, author = {Lies Decoutere}, title = {Analysis of the Association between Interleukin-10 Plasma Levels and the Association of Single and Multiple Organ Failure following Severe Multiple Trauma}, journal = {Analyse der Assoziation zwischen Interleukin-10 Plasmaspiegeln und der Inzidenz von einfachem und mehrfachem Organversagen nach Polytrauma}, url = {https://nbn-resolving.org/urn:nbn:de:gbv:9-000036-4}, year = {2006}, abstract = {Severe trauma results in alterations in immune functions, correlated with a dysbalanced cytokine synthesis. This imbalance endangers severely injured patients for post-traumatic complications such as MODS, liver failure, renal dysfunction and ARDS. IL-10, a powerful immunosuppressive cytokine, plays a central role in the immune response after severe trauma. The relevance of IL-10 for single and multiple organ failure was studied in a prospective study at a level I trauma center. Blood was systematically obtained from a total of 118 severely injured [median (IQR) ISS=34 (27-34)] patients. IL-10 plasma levels were measured by ELISA. Patients showed elevated IL-10 levels throughout the whole observation period of 5 days. IL-10 plasma levels rose rapidly after trauma and gradually declined towards day 5. Patients who developed complications demonstrated significantly elevated IL-10 levels compared with patients who did not. The odds of developing MODS were 9.6 times greater in patients with IL-10 plasma levels higher than 124 pg/mL 6 hours after arrival at the ICU. Multivariate analysis showed that IL-10 plasma levels >124 pg/mL at time-point 6h, severe head injury and an arterial pH <7.34 were simultaneously significant predictors of the development of MODS in severely injured patients. The dynamic with rapid increase and gradual decline in IL-10 plasma levels indicated that IL-10 is a marker of the initial damage to the organism caused by trauma, rather than a marker of somatic dysregulations.}, language = {en} }