TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Schauer, Anja E.
A1  - Klassert, Tilman E.
A1  - von Lachner, Carolin
A1  - Riebold, Diana
A1  - Schneeweiß, Anne
A1  - Stock, Magdalena
A1  - Müller, Mario M.
A1  - Hammerschmidt, Sven
A1  - Bufler, Philip
A1  - Seifert, Ulrike
A1  - Dietert, Kristina
A1  - Dinarello, Charles A.
A1  - Nold, Marcel F.
A1  - Gruber, Achim D.
A1  - Nold-Petry, Claudia A.
A1  - Slevogt, Hortense
T1  - IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia
JF  - Journal of Innate Immunity
N2  - Streptococcus pneumoniae infections can lead to severe complications with excessive immune activation and tissue damage. Interleukin-37 (IL-37) has gained importance as a suppressor of innate and acquired immunity, and its effects have been therapeutic as they prevent tissue damage in autoimmune and inflammatory diseases. By using RAW macrophages, stably transfected with human IL-37, we showed a 70% decrease in the cytokine levels of IL-6, TNF-α, and IL-1β, and a 2.2-fold reduction of the intracellular killing capacity of internalized pneumococci in response to pneumococcal infection. In a murine model of infection with S. pneumoniae, using mice transgenic for human IL-37b (IL-37tg), we observed an initial decrease in cytokine expression of IL-6, TNF-α, and IL-1β in the lungs, followed by a late-phase enhancement of pneumococcal burden and subsequent increase of proinflammatory cytokine levels. Additionally, a marked increase in recruitment of alveolar macrophages and neutrophils was noted, while TRAIL mRNA was reduced 3-fold in lungs of IL-37tg mice, resulting in necrotizing pneumonia with augmented death of infiltrating neutrophils, enhanced bacteremic spread, and increased mortality. In conclusion, we have identified that IL-37 modulates several core components of a successful inflammatory response to pneumococcal pneumonia, which lead to increased inflammation, tissue damage, and mortality.
KW  - -
KW  - Interleukin-37
KW  - Immunosuppression
KW  - Inflammation
KW  - Antibacterial host defense
KW  - Pneumococcal pneumonia
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31174
UR  - www.karger.com/jin
SN  - 1662-811X
SS  - 1662-811X
SN  - 1662-8128
SS  - 1662-8128
U6  - https://doi.org/10.1159/000469661
DO  - https://doi.org/10.1159/000469661
PM  - 28601872
VL  - 9
IS  - 4
SP  - 403
EP  - 418
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -