TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Goette, Andreas A1 - Bukowska, Alicja A1 - Lillig, Christopher H. A1 - Lendeckel, Uwe T1 - Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation JF - Frontiers in Physiology N2 - Patients with atrial fibrillation (AF) often present with typical angina pectoris and mildly elevated levels of cardiac troponin (non-ST-segment elevation myocardial infarction) during an acute episode of AF. However, in a large proportion of these patients, significant coronary artery disease is excluded by coronary angiography, which suggests that AF itself influences myocardial blood flow. The present review summarizes the effect of AF on the occurrence of ventricular oxidative stress, redox-sensitive signaling pathways and gene expression, and microcirculatory flow abnormalities in the left ventricle. KW - angiotensin KW - atrial fibrillation KW - microvascular flow KW - oxidative stress Y1 - 2012 UN - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-32819 SN - 1664-042X SS - 1664-042X U6 - https://doi.org/10.3389/fphys.2012.00236 DO - https://doi.org/10.3389/fphys.2012.00236 VL - 3 IS - 236 SP - 9 S1 - 9 PB - Frontiers Media S.A. CY - Lausanne ER -