@phdthesis{Harb2013,
  author    = {Ali Harb},
  title     = {Association between the Insulin-Like Growth Factor axis in serum and Periodontitis in the Study of Health in Pomerania: An exploratory study},
  journal    = {Zusammenhang zwischen der IGF-Achse in Serum und Parodontitis in der bev{\"o}lkerungsbezogenen Study of Health in Pomerania (SHIP)},
  url       = {https://nbn-resolving.org/urn:nbn:de:gbv:9-001639-6},
  year      = {2013},
  abstract  = {Aim: To evaluate the association of Insulin-like Growth Factor (IGF) I related variables with periodontitis in the population-based Study of Health in Pomerania (SHIP). Material and Methods: From the cross-sectional SHIP, 2293 subjects with clinical attachment loss (CAL) data and 2398 subjects with tooth count data aged 20-59 years were analysed. Serum IGF-I and IGF binding protein (BP)-3 levels were determined by chemiluminescence immunoassays. Linear and logistic regressions with fractional polynomials were used to study associations between IGF-related variables and mean CAL or high tooth loss. For non-linear relations between IGFBP-3 and mean CAL, graphical presentations of fractional polynomials were used to deduce knots for linear splines. Results: In fully adjusted models, for serum IGFBP-3 values ≤1200 ng/mL, mean CAL increased significantly for decreasing serum IGFBP-3 levels (B=-0.027 (95\% CI, -0.049; -0.005), p=0.02). The odds for high tooth loss decreased significantly for high serum IGFBP-3 values (OR=0.97 (0.95; 0.99), p=0.02). Serum IGF-I levels and the IGF-I/IGFBP-3 ratio were not related to mean CAL or tooth loss after full adjustment. Conclusions: Low serum IGFBP-3 levels might be associated with higher levels of periodontal disease. Neither serum IGF-I nor IGF-I/IGFBP-3 ratios were associated with periodontitis.},
  language  = {en}
}