TY  - THES
U1  - Dissertation / Habilitation
A1  - Kozulovic, Klaudija
T1  - Untersuchungen zur Expression von P-Glycoprotein an Hirngewebsproben bei Patienten mit pharmacoresistenter Epilepsie
N2  - keine Angaben
N2  - Slices of human cortical tissue from epilepsy surgery were investigated. This were patients with medically intractable epilepsy inspite of sufficient serum antiepileptic drug concentrations. The human P-Glycoprotein (P-Glycoprotein, MDR 1) is an ATP-driven transporter for hydrophobic drugs and causes multidrug resistance in cancer. P-Glycoprotein is localised in the endothelial cells of vessels of the brain and it contributions to the blood brain barrier (BBB), since some AEDs (antiepileptic drugs) are substrates of P-Glycoprotein they can not be effective due to the efflux transport. It is suggested that a medically intractable epilepsy on its own does not ineritably lead to an increased P-Glycoprotein expression , but it does in combination with focal cortical dysplasia.
KW  - Epilepsie
KW  - ATP-Stoffwechsel
Y2  - 2005
U6  - https://nbn-resolving.org/urn:nbn:de:gbv:9-000071-9
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-000071-9
ER  -