TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Grenacher, Lars
A1  - Strauß, Albert
A1  - Bergmann, Frank
A1  - Birdsey, Matthew
A1  - Mayerle, Julia
T1  - Cyst Features and Risk of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Imaging and Pathology
JF  - Visceral Medicine
N2  - Background: Intraductal papillary mucinous neoplasms (IPMNs) display diverse macroscopic, histological, and immunohistochemical characteristics with typical morphological appearance in magnetic resonance imaging. Depending on those, IPMNs may show progression into invasive carcinomas with variable frequency. Overall, IPMN-associated invasive carcinomas are found in about 30% of all IPMNs, revealing phenotpyes comparable with conventional ductal adenocarcinomas or mucinous (colloid) carcinomas of the pancreas. In Sendai-negative side-branch IPMNs, however, the annual risk of the development of invasive cancer is 2%; thus, risk stratification with regard to imaging and preoperative biomarkers and cytology is mandatory. Methods and Results: The present study addresses the radiological and interventional preoperative measures including histological features to determine the risk of malignancy and the prognosis of IPMNs. Conclusion: While preoperative imaging largely relies on the detection of macroscopic features of IPMNs, which are associated with a divergent risk of malignant behavior, in resected specimens the determination of the grade of dysplasia and the detection of an invasive component are the most important features to estimate the prognosis of IPMNs.
KW  - -
KW  - Pancreas
KW  - Intraductal papillary mucinous neoplasm
KW  - IPMN
KW  - Cystic lesion
Y1  - 2015
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30677
SN  - 2297-4725
SS  - 2297-4725
SN  - 2297-475X
SS  - 2297-475X
U6  - https://doi.org/10.1159/000375254
DO  - https://doi.org/10.1159/000375254
PM  - 26288613
VL  - 31
IS  - 1
SP  - 31
EP  - 37
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -