TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Sümnig, Ariane
A1  - Mayer, Beate
A1  - Kiefel, Volker
A1  - Greinacher, Andreas
A1  - Salama, Abdulgabar
T1  - ‘Chameleonic' Serological Findings Leading to Life-Threatening Hemolytic Transfusion Reactions
JF  - Transfusion Medicine and Hemotherapy
N2  - Background: The phenomena of co-incidence of transfusion-induced allo- and autoantibodies, blockage and/or loss of red blood cell (RBC) antigens are conspicuous and may result in confusion and misdiagnosis. Case Report: A 67-year-old female was transferred to the intensive care unit due to hemolysis which developed 2 days following transfusion of three Rh(D)-negative RBC units in the presence of strongly reactive autoantibodies. Standard serological testing and genotyping were performed. Upon arrival, the patient was typed as Ccddee. Her hemolysis was decompensated, and an immediate blood transfusion was required. In addition, direct and indirect antiglobulin tests (DAT and IAT) as well as the eluate were strongly positive. Emergency transfusion of Rh(D)-negative RBCs resulted in increased hemolysis and renal failure. An exhaustive testing revealed anti-D, anti-c, CCddee phenotype and CCD.ee genotype. Three units of cryopreserved CCddee RBCs were transfused, and the patient's condition immediately improved. The discrepancy between Rh-D phenotyping and genotyping was likely caused by masking of the D-epitopes by the autoantibodies. In fact, further enquiry revealed that the patient had been phenotyped as Rh(D)-positive 6 months ago and had been transfused at that time following hip surgery. Conclusion: The phenomena of transfusion-induced autoantibodies, masked alloantibodies, antigen blockage and/or loss are rare but important features which should be considered in patients presenting with autoimmune hemolytic anemia and/or hemolytic transfusion reactions.
KW  - -
KW  - Transfusion reaction
KW  - Auto-anti-D
KW  - Rh(D)-blocked phenomenon
KW  - Hemolytic anemia
KW  - Antigen suppression
Y1  - 2015
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30758
SN  - 1660-3796
SS  - 1660-3796
SN  - 1660-3818
SS  - 1660-3818
U6  - https://doi.org/10.1159/000437198
DO  - https://doi.org/10.1159/000437198
PM  - 26696804
VL  - 42
IS  - 5
SP  - 340
EP  - 343
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -