TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Daeschlein, G.
A1  - Alborova, J.
A1  - Patzelt, A.
A1  - Kramer, A.
A1  - Lademann, J.
T1  - Kinetics of Physiological Skin Flora in a Suction Blister Wound Model on Healthy Subjects after Treatment with Water-Filtered Infrared-A Radiation
JF  - Skin Pharmacology and Physiology
N2  - The effect of water-filtered infrared-A radiation (wIRA) on normal skin flora was investigated by generating experimental wounds on the forearms of volunteers utilizing the suction blister technique. Over 7 days, recolonization was monitored parallel to wound healing. Four groups of treatment were compared: no therapy (A), dexpanthenol cream once daily (B), 20 min wIRA irradiation at 30 cm distance (C), and wIRA irradiation for 30 min once daily together with dexpanthenol cream once daily (D). All treatments strongly inhibited the recolonization of the wounds. Whereas dexpanthenol completely suppressed recolonization over the test period, recolonization after wIRA without (C) and in combination with dexpanthenol (D) was suppressed, but started on day 5 with considerably higher amounts after the combination treatment (D). Whereas the consequence without treatment (A) was an increasing amount of physiological skin flora including coagulase-negative staphylococci, all treatments (B–D) led to a reduction in physiological skin flora, including coagulase-negative staphylococci. In healthy volunteers, wIRA alone and in combination with dexpanthenol strongly inhibited bacterial recolonization with physiological skin flora after artificial wound setting using a suction-blister wound model. This could support the beneficial effects of wIRA in the promotion of wound healing.
KW  - -
KW  - Water-filtered infrared-A radiation
KW  - Suction blister
KW  - Wound colonization
KW  - Energy supply
KW  - Oxygen supply
Y1  - 2011
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30825
SN  - 1660-5527
SS  - 1660-5527
SN  - 1660-5535
SS  - 1660-5535
U6  - https://doi.org/10.1159/000332753
DO  - https://doi.org/10.1159/000332753
PM  - 22123525
VL  - 25
IS  - 2
SP  - 73
EP  - 77
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -