TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Lademann, O.
A1  - Kramer, A.
A1  - Richter, H.
A1  - Patzelt, A.
A1  - Meinke, M.C.
A1  - Czaika, V.
A1  - Weltmann, K.-D.
A1  - Hartmann, B.
A1  - Koch, S.
T1  - Skin Disinfection by Plasma-Tissue Interaction: Comparison of the Effectivity of Tissue-Tolerable Plasma and a Standard Antiseptic
JF  - Skin Pharmacology and Physiology
N2  - Wound healing disorders frequently occur due to biofilm formation on wound surfaces requiring conscientious wound hygiene. Often, the application of conventional liquid antiseptics is not sufficient and sustainable as (1) the borders and the surrounding of chronic wounds frequently consist of sclerotic skin, impeding an effectual penetration of these products, and (2) the hair follicles representing the reservoir for bacterial recolonization of skin surfaces are not affected. Recently, it has been reported that tissue-tolerable plasma (TTP), which is used at a temperature range between 35 and 45°C, likewise has disinfecting properties. In the present study, the effectivity of TTP and a standard liquid antiseptic was compared in vitro on porcine skin. The results revealed that TTP was able to reduce the bacterial load by 94%, although the application of the liquid antiseptic remained superior as it reduced the bacteria by almost 99%. For in vivo application, however, TTP offers several advantages. On the one hand, TTP enables the treatment of sclerotic skin as well, and on the other hand, a sustainable disinfection can be realized as, obviously, also the follicular reservoir is affected by TTP.
KW  - -
KW  - Wound
KW  - Skin barrier
KW  - Stratum corneum
KW  - Hair follicle
KW  - Bacteria
KW  - Fungi
Y1  - 2011
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30848
SN  - 1660-5527
SS  - 1660-5527
SN  - 1660-5535
SS  - 1660-5535
U6  - https://doi.org/10.1159/000329913
DO  - https://doi.org/10.1159/000329913
PM  - 21709431
VL  - 24
IS  - 5
SP  - 284
EP  - 288
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -