TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - König, Maximilian
A1  - Gollasch, Maik
A1  - Spira, Dominik
A1  - Buchmann, Nikolaus
A1  - Hopfenmüller, Werner
A1  - Steinhagen-Thiessen, Elisabeth
A1  - Demuth, Ilja
T1  - Mild-to-Moderate Chronic Kidney Disease and Geriatric Outcomes: Analysis of Cross-Sectional Data from the Berlin Aging Study II
JF  - Gerontology
N2  - Background: Mild-to-moderate chronic kidney disease (CKD G3a) is prevalent in older adults. Substantial evidence suggests that individuals with advanced CKD face a high risk for common geriatric conditions, like functional impairment and cognitive decline, whereas the relationships between mild-to-moderate CKD and functional impairment and cognitive decline, but also poor nutritional status and mood disorders, are still unclear. Objective: The aim of this study was to explore associations between mild-to-moderate CKD and impairments in the core domains of geriatric assessment (GA) in a large cohort of community-dwelling older adults. Methods: This was a cross-sectional analysis of 1,476 participants of the Berlin Aging Study II. Study participants were stratified as to presence or absence of CKD G3a (estimated glomerular filtration rate [eGFR] 45-59 mL/min/1.73 m<sup>2</sup> vs. eGFR ≥60 mL/min/1.73 m<sup>2</sup>). GA comprised the following instruments: the Activities of Daily Living Scale (ADL), the Timed up and Go (TUG), the Tinetti test (Tinetti), the Mini-Mental-State Examination (MMSE), the Geriatric Depression Scale (GDS), and the Mini Nutritional Assessment (MNA). We used logistic regression models to estimate multivariable-adjusted associations between CKD G3a and impairments in the respective domains. Results: A total of 282 subjects with mild-to-moderate CKD (CKD G3a) were identified (19.1%). Overall, the prevalence of impairments identified was higher among subjects with compared to without CKD G3a (21 vs. 15.9%, p = 0.043). In multivariable-adjusted models, CKD G3a was consistently associated with increased odds of an impaired gait performance as to the TUG (adjusted odds ratio 2.06, 95% CI 1.04-4.09). In contrast, on average, individuals with and without CKD G3a did not differ as to their results in the MMSE, the ADL, the MNA, and the GDS. Conclusion: GA identified impairments in 21 versus 15.9% of older adults with and without mild-to-moderate CKD, respectively. However, except for an increased likelihood of impaired gait performance (TUG) with mild-to-moderate CKD, we did not find independent associations between mild-to-moderate CKD and geriatric conditions.
KW  - -
KW  - Physical function
KW  - Cognition
KW  - Mobility
KW  - Nutrition
KW  - Chronic kidney disease
KW  - Assessment
Y1  - 2017
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31215
UR  - www.karger.com/ger
SN  - 0304-324X
SS  - 0304-324X
SN  - 1423-0003
SS  - 1423-0003
U6  - https://doi.org/10.1159/000484140
DO  - https://doi.org/10.1159/000484140
PM  - 29183010
VL  - 64
IS  - 2
SP  - 118
EP  - 126
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -