TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Le, Nha
A1  - Vinci, Alessio
A1  - Schober, Marvin
A1  - Krug, Sebastian
A1  - Javed, Muhammad A.
A1  - Kohlmann, Thomas
A1  - Sund, Malin
A1  - Neesse, Albrecht
A1  - Beyer, Georg
T1  - Real-World Clinical Practice of Intensified Chemotherapies for Metastatic Pancreatic Cancer: Results from a Pan-European Questionnaire Study
JF  - Digestion
N2  - Introduction: Recently, FOLFIRINOX and gemcitabine + nab-paclitaxel have been introduced as a novel intensified chemotherapy regimen for patients with metastasized pancreatic cancer. This study aims to analyze the real-world clinical practice with FOLFIRINOX and gemcitabine + nab-paclitaxel across Europe. Methods: Invitations to participate in an anonymous web-based questionnaire were sent via e-mail to 5,420 doctors in 19 European countries through the network of national gastroenterological, oncological, surgical and pancreatic societies as well as the European Pancreatic Club. The questionnaire consisted of 20 questions, 14 regarding the use of intensified chemotherapy, 4 regarding demographics of the participants, and 1 to verify the active involvement in the management of metastatic pancreatic cancer. Results: Two hundred and thirteen responses were received and 153 entries were valid for analysis. Of those, 63.4% came from an academic institution, 51% were oncologists, and 52% treated more than 25 cases per year. A majority of responses (71%) were from Italy (40%), Germany (23%), and Spain (8%). As first-line therapy, 11% used gemcitabine +/- erlotinib, 42% used FOLFIRINOX, and 47% used gemcitabine + nab-paclitaxel. Of the intensified regimens, both were applied to equal parts, but the likelihood of protocol deviation was higher when using FOLFIRINOX (p < 0.01). FOLFIRINOX was considered more toxic than gemcitabine + nab-paclitaxel (neutropenia 88 vs. 68%; polyneuropathy 42 vs. 41%; rapid deterioration 42 vs. 31%). FOLFIRINOX was rated to achieve longer survival with an acceptable quality of life (52 vs. 44%). Moreover, 57% of participants thought that gemcitabine + nab-paclitaxel should be the backbone for further clinical trials in pancreatic cancer. Conclusion: Intensified chemotherapy is widely used in pancreatic cancer patients in Europe following its recent clinical approval. Interestingly, nab-paclitaxel and FOLFIRINOX were used at comparable frequency although the latter had to be de-escalated more often.
KW  - -
KW  - Pancreatic cancer
KW  - Palliative chemotherapy
KW  - FOLFIRINOX
KW  - Nab-paclitaxel
Y1  - 2016
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31375
SN  - 0012-2823
SS  - 0012-2823
SN  - 1421-9867
SS  - 1421-9867
U6  - https://doi.org/10.1159/000453257
DO  - https://doi.org/10.1159/000453257
PM  - 28030863
VL  - 94
IS  - 4
SP  - 222
EP  - 229
PB  - S. Karger AG
CY  - Basel, Switzerland
ER  -