TY - JOUR U1 - Wissenschaftlicher Artikel A1 - Goltz, Annemarie A1 - Janowitz, Deborah A1 - Hannemann, Anke A1 - Nauck, Matthias A1 - Hoffmann, Johanna A1 - Seyfart, Tom A1 - Völzke, Henry A1 - Terock, Jan A1 - Grabe, Hans J. T1 - Association of Brain-Derived Neurotrophic Factor and Vitamin D with Depression and Obesity: A Population-Based Study JF - Neuropsychobiology N2 - Background: Depression and obesity are widespread and closely linked. Brain-derived neurotrophic factor (BDNF) and vitamin D are both assumed to be associated with depression and obesity. Little is known about the interplay between vitamin D and BDNF. We explored the putative associations and interactions between serum BDNF and vitamin D levels with depressive symptoms and abdominal obesity in a large population-based cohort. Methods: Data were obtained from the population-based Study of Health in Pomerania (SHIP)-Trend (n = 3,926). The associations of serum BDNF and vitamin D levels with depressive symptoms (measured using the Patient Health Questionnaire) were assessed with binary and multinomial logistic regression models. The associations of serum BDNF and vitamin D levels with obesity (measured by the waist-to-hip ratio [WHR]) were assessed with binary logistic and linear regression models with restricted cubic splines. Results: Logistic regression models revealed inverse associations of vitamin D with depression (OR = 0.966; 95% CI 0.951–0.981) and obesity (OR = 0.976; 95% CI 0.967–0.985). No linear association of serum BDNF with depression or obesity was found. However, linear regression models revealed a U-shaped association of BDNF with WHR (p < 0.001). Conclusion: Vitamin D was inversely associated with depression and obesity. BDNF was associated with abdominal obesity, but not with depression. At the population level, our results support the relevant roles of vitamin D and BDNF in mental and physical health-related outcomes. KW - - KW - Brain-derived neurotrophic factor KW - Vitamin D KW - Depression KW - Obesity Y1 - 2018 UN - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-33418 SN - 0302-282X SS - 0302-282X SN - 1423-0224 SS - 1423-0224 U6 - https://doi.org/10.1159/000489864 DO - https://doi.org/10.1159/000489864 PM - 29920493 VL - 76 IS - 4 SP - 171 EP - 181 PB - S. Karger AG CY - Basel, Switzerland ER -