@article{SchneidewindNeumannZimmermannetal.2019,
  author    = {Schneidewind, Laila and Neumann, Thomas and Zimmermann, Kathrin and Weigel, Martin and Schmidt, Christian Andreas and Kr{\"u}ger, William},
  title     = {Is BK Virus-Associated Cystitis a Generalized Epithelial Disease?},
  journal   = {Acta Haematologica},
  volume    = {141},
  number    = {2},
  issn      = {0001-5792},
  doi       = {10.1159/000494748},
  institution = {Friedrich-Loeffler-Institut f{\"u}r Medizinische Mikrobiologie},
  pages     = {65 -- 67},
  year      = {2019},
  abstract  = {BK polyomavirus-associated haemorrhagic cystitis (BKHC) is a complication after allogeneic stem cell transplantation, which can occur in 5-60\% of the cases. BK viruria alone can also occur in up to 100\%. BKHC can lead to severe morbidity in stem cell-transplanted patients, but data about this disease is limited. Consequently, we conducted a prospective unicentric non-interventional trial on BKHC as well as BK viruria after first adult allogeneic stem cell transplantation with a follow-up time of 1 year after inpatient treatment. Between November 2013 and December 2015, we were able to include 40 adult patients with a mean age of 52.8 years. Twenty-seven (67.5\%) of these patients were male and 13 (32.5\%) were female. Acute myeloid leukaemia was the most frequent underlying disease (n = 15; 37.5\%). Only 1 patient developed BKHC during inpatient treatment (n = 1; 2.5\%), but BK viruria was frequent (n = 11; 27.5\%) during inpatient treatment as well as in the follow-up time (n = 14; 35\%). Interestingly, BK viruria was significantly associated with mucositis (p = 0.038) and number of transfused platelet concentrates (p = 0.001). This unexpected association will be discussed and needs further investigation.},
  subject      = {-},
  language  = {en}
}