TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Nicolai, Oliver
A1  - Pötschke, Christian
A1  - Raafat, Dina
A1  - van der Linde, Julia
A1  - Quosdorf, Sandra
A1  - Laqua, Anna
A1  - Heidecke, Claus-Dieter
A1  - Berek, Claudia
A1  - Darisipudi, Murthy N.
A1  - Binder, Christoph J.
A1  - Bröker, Barbara M.
T1  - Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis
JF  - Frontiers in Immunology
N2  - In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. The specificity of this antibody response was studied in serum and at the single cell level using a broad panel of bacterial, sepsis-unrelated as well as self-antigens. Whereas an antibacterial IgM/IgG response was rarely observed, studies at the single-cell level revealed that IgM antibodies, in particular, were largely polyreactive. Interestingly, at least 16% of the IgM mAbs and 20% of the IgG mAbs derived from post-septic mice showed specificity for oxidation-specific epitopes (OSEs), which are known targets of the innate/adaptive immune response. This identifies those self-antigens as the main target of B cell responses in sepsis.
KW  - -
KW  - CASP
KW  - polymicrobial sepsis
KW  - B cell response
KW  - polyreactive antibodies
KW  - oxidation-specific epitopes
Y1  - 2020
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-38881
SN  - 1664-3224
SS  - 1664-3224
U6  - https://doi.org/https://doi.org/10.3389/fimmu.2020.01570
DO  - https://doi.org/https://doi.org/10.3389/fimmu.2020.01570
VL  - 11
PB  - Frontiers Media S.A.
CY  - Lausanne
ER  -