TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Colberg, Lisa
A1  - Cammann, Clemens
A1  - Greinacher, Andreas
A1  - Seifert, Ulrike
T1  - Structure and function of the ubiquitin‐proteasome system in platelets
JF  - Journal of Thrombosis and Haemostasis
N2  - Abstract
Platelets are small anucleate blood cells with a life span of 7 to 10 days. They are main regulators of hemostasis. Balanced platelet activity is crucial to prevent bleeding or occlusive thrombus formation. Growing evidence supports that platelets also participate in immune reactions, and interaction between platelets and leukocytes contributes to both thrombosis and inflammation. The ubiquitin‐proteasome system (UPS) plays a key role in maintaining cellular protein homeostasis by its ability to degrade non‐functional self‐, foreign, or short‐lived regulatory proteins. Platelets express standard and immunoproteasomes. Inhibition of the proteasome impairs platelet production and platelet function. Platelets also express major histocompatibility complex (MHC) class I molecules. Peptide fragments released by proteasomes can bind to MHC class I, which makes it also likely that platelets can activate epitope specific cytotoxic T lymphocytes (CTLs). In this review, we focus on current knowledge on the significance of the proteasome for the functions of platelets as critical regulators of hemostasis as well as modulators of the immune response.
KW  - -
KW  - antigen presentation
KW  - MHC class I
KW  - platelet activation
KW  - proteasome endopeptidase complex
KW  - ubiquitin
Y1  - 2020
UN  - https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-40561
SN  - 1538-7836
SS  - 1538-7836
U6  - https://doi.org/10.1111/jth.14730
DO  - https://doi.org/10.1111/jth.14730
VL  - 18
IS  - 4
SP  - 771
EP  - 780
PB  - Wiley
CY  - Hoboken, New Jersey
ER  -