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Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A Systematic Review of the Literature

  • The objective of this systematic review was to discuss our current understanding of the complex relationship between chronic obstructive pulmonary disease (COPD) and type-2 diabetes mellitus (T2DM). We performed a systematic search of the literature related to both COPD and diabetes using PubMed. Relevant data connecting both diseases were compiled and discussed. Recent evidence suggests that diabetes can worsen the progression and prognosis of COPD; this may result from the direct effects of hyperglycemia on lung physiology, inflammation or susceptibility to bacterial infection. Conversely, it has also been suggested that COPD increases the risk of developing T2DM as a consequence of inflammatory processes and/or therapeutic side effects related to the use of high-dose corticosteroids. In conclusion, although there is evidence to support a connection between COPD and diabetes, additional research is needed to better understand these relationships and their possible implications.

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Metadaten
Author: Sven Gläser, Stefan Krüger, Martin Merkel, Peter Bramlage, Felix J.F. Herth
URN:urn:nbn:de:gbv:9-opus-32209
DOI:https://doi.org/https://doi.org/10.1159/000369863
ISSN:0025-7931
ISSN:1423-0356
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/25677307
Parent Title (English):Respiration
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2015/02/13
Release Date:2022/05/09
Tag:Chronic obstructive pulmonary disease; Inflammation; Pathophysiological relationship; Type-2 diabetes
GND Keyword:-
Volume:89
Article Number:3
First Page:253
Last Page:264
Faculties:Universitätsmedizin / Klinik und Poliklinik für Innere Medizin
Licence (German):License LogoUrheberrechtlich geschützt