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A Comprehensive View on the Human Antibody Repertoire Against Staphylococcus aureus Antigens in the General Population

  • Our goal was to provide a comprehensive overview of the antibody response to Staphylococcus aureus antigens in the general population as a basis for defining disease-specific profiles and diagnostic signatures. We tested the specific IgG and IgA responses to 79 staphylococcal antigens in 996 individuals from the population-based Study of Health in Pomerania. Using a dilution-based multiplex suspension array, we extended the dynamic range of specific antibody detection to seven orders of magnitude, allowing the precise quantification of high and low abundant antibody specificities in the same sample. The observed IgG and IgA antibody responses were highly heterogeneous with differences between individuals as well as between bacterial antigens that spanned several orders of magnitude. Some antigens elicited significantly more IgG than IgA and vice versa. We confirmed a strong influence of colonization on the antibody response and quantified the influence of sex, smoking, age, body mass index, and serum glucose on anti-staphylococcal IgG and IgA. However, all host parameters tested explain only a small part of the extensive variability in individual response to the different antigens of S. aureus.

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Metadaten
Author: Tanja C. Meyer, Stephan Michalik, Silva Holtfreter, Stefan Weiss, Nele Friedrich, Henry Völzke, Thomas Kocher, Christian Kohler, Frank Schmidt, Barbara M. Bröker, Uwe Völker
URN:urn:nbn:de:gbv:9-opus-44378
DOI:https://doi.org/10.3389/fimmu.2021.651619
ISSN:1664-3224
Parent Title (English):Frontiers in Immunology
Publisher:Frontiers Media S.A.
Document Type:Article
Language:English
Date of first Publication:2021/03/10
Release Date:2021/06/10
Tag:anti-; antibody repertoire; host-pathogen-interaction; immunoproteomics
GND Keyword:-
Volume:12
Faculties:Universitätsmedizin / Institut für Immunologie u. Transfusionsmedizin - Abteilung Immunologie
Licence (German):License LogoCreative Commons - Namensnennung