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Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures

  • Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.

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Metadaten
Author: Annett Mikolasch, Veronika Hahn
URN:urn:nbn:de:gbv:9-opus-57218
DOI:https://doi.org/10.3390/microorganisms9112199
ISSN:2076-2607
Parent Title (English):Microorganisms
Publisher:MDPI
Editor: Annett Mikolasch, Mariam Gaid
Document Type:Article
Language:English
Date of first Publication:2021/10/21
Release Date:2021/11/08
Tag:antibacterial activity; antimicrobial resistance (AMR); biotransformation; laccase; methicillin-resistant; multidrug resistance (MDR); sulfonamide antibiotics; β-lactam antibiotics
GND Keyword:-
Volume:9
Issue:11