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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan

  • Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.

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Author: Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/34244448
Parent Title (English):Stroke and Vascular Neurology
Publisher:BMJ Publishing Group Ltd
Place of publication:London
Document Type:Article
Year of first Publication:2021
Release Date:2022/07/06
Tag:COVID-19; MRI; blood platelets; complication; haemorrhage
GND Keyword:-
Page Number:3
First Page:668
Last Page:670
Faculties:Universitätsmedizin / Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell