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The association between thyroid function biomarkers and attention deficit hyperactivity disorder

  • The relation between thyroid function biomarkers and attention deficit hyperactivity disorder (ADHD) in children and adolescents is currently unclear. Cross-sectional data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS Baseline) was analyzed to assess the association between thyroid function biomarkers and ADHD in a population-based, nationally representative sample. The study cohort included 11,588 children and adolescents with 572 and 559 having an ADHD diagnosis or symptoms, respectively. ADHD symptoms were assessed through the Inattention/Hyperactivity subscale of the Strength and Difficulties Questionnaire. ADHD diagnosis was determined by a physician or psychologist. Serum thyroid stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) concentrations were determined enzymatically. Adjusted regression models were used to relate serum TSH, fT3, and fT4 with risk for ADHD diagnosis or symptoms. In children, a 1 mIU/l higher TSH was related to a 10% lower risk (odds ratio [OR] 0.90; 95% confidence interval [CI] 0.81–1.00) of ADHD diagnosis. We found a significant positive association between fT3 and continuously assessed ADHD symptoms in children (β 0.08; 95% CI 0.03–0.14). Our results suggest that physical maturity may influence the association between thyroid function biomarkers and risk for ADHD.

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Author: Diana AlbrechtORCiD
Title Additional (German):Die Assoziation von Biomarkern der Schilddrüsenfunktion mit der Aufmerksamkeitsdefizit- und Hyperaktivitätsstörung
Referee:Prof. Dr. med. Henry Völzke, Prof. Dr. Dr. med. Dagmar Führer-Sakel
Advisor:Prof. Dr. med. Henry Völzke
Document Type:Doctoral Thesis
Year of Completion:2023
Date of first Publication:2023/10/17
Granting Institution:Universität Greifswald, Universitätsmedizin
Date of final exam:2023/09/20
Release Date:2023/10/17
GND Keyword:Epidemiologie , Aufmerksamkeitsdefizit-Syndrom , Schilddrüse
Page Number:63
Faculties:Universitätsmedizin / Institut für Community Medicine
DDC class:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin und Gesundheit