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Commissioning the digital mass-filter/ion-trap module for the MS SPIDOC prototype

  • The combination of a linear quadrupole ion-filter and linear Paul trap operated with a rectangular guiding field for the filtering and accumulation of ions within the Mass Spectrometry for Single Particle Imaging of Dipole Oriented protein Complexes (MS SPIDOC) prototype [T. Kierspel et al., Anal. Bioanal. Chem., published online] is characterized. Using cationic caesium-iodide clusters, the ion-separation performance, ion accumulation, cooling, and ejection via in-trap pin electrodes is evaluated. Furthermore, proof-of-principle measurements are performed with 64 kDa multiply-charged non-covalent protein complexes of human hemoglobin and 804 kDa non-covalent complex of GroEL, to demonstrate that the module meets the criteria to handle high-mass ions which are the main objective of the MS SPIDOC project. The setup's performance is found to be in line with previous results from ion-trajectory simulations [F. Simke et al., Int. J. Mass Spectrom.473 (2022) 116779].

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Author: Florian SimkeORCiD, Paul FischerORCiD, Tomislav Damjanović, Alan KádekORCiD, Thomas KierspelORCiD, Kristina LorenzenORCiD, Charlotte UetrechtORCiD, Lutz Schweikhard
Parent Title (English):Journal of Instrumentation
Publisher:IOP Publishing
Place of publication:London
Document Type:Article
Date of first Publication:2023/10/18
Release Date:2023/11/15
Tag:Instrumentation for FEL; Instrumentation for radioactive beams (fragmentation devices, fragment and isotope, separators incl. ISOL, isobar separators, ion and atom traps, weak-beam diagnostics, radioactive-beam ion sources); Mass spectrometers
Article Number:P10021
Faculties:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik
Licence (German):License LogoCreative Commons - Namensnennung