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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-32461

Severe Disseminated Coagulopathy Caused by Adenocarcinoma with Bone Marrow Metastasis

  • Background: Patients with mucin-producing adenocarcinoma have an increased risk for venous and arterial thrombosis. When these patients present with thrombocytopenia, disseminated intravascular coagulopathy (DIC) is often the underlying cause. Case Report: We report 2 patients who were admitted due to bleeding symptoms of unknown cause, in whom further workup revealed adenocarcinoma-induced DIC. Conclusion: In elderly patients presenting with signs of DIC, such as reduced fibrinogen levels, elevated prothrombin time, elevated D-dimer, and thrombocytopenia, without any obvious reason (e.g., sepsis), adenocarcinoma-associated coagulopathy should be considered as the underlying cause. Paradoxically, in these patients bleeding symptoms improve when the patient is sufficiently anti-coagulated with low molecular weight heparin. Treatment of the underlying disease is of central importance in controlling acute or chronic DIC associated with malignant diseases and chemotherapy should be started as soon as possible.

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Metadaten
Author: Anne F. Klenner, Andreas Greinacher, Anna Kuvikova, Gottfried Dölken, Christoph Busemann
URN:urn:nbn:de:gbv:9-opus-32461
DOI:https://doi.org/10.1159/000350327
ISSN:2296-5270
ISSN:2296-5262
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23689225
Parent Title (English):Oncology Research and Treatment
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2013/04/02
Release Date:2020/10/08
Tag:Adenocarcinoma, Bone marrow metastasis, Disseminated intravascular coagulation, Thrombocytopenia
GND Keyword:-
Volume:36
Issue:5
First Page:292
Last Page:294
Faculties:Universitätsmedizin / Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin
Universitätsmedizin / Klinik und Poliklinik für Innere Medizin
Licence (German):License LogoUrheberrechtlich geschützt