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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-40875

Effect of periodontal therapy on adipokine biomarkers in overweight

  • Abstract Aim The aim of this study was to evaluate the effect of non‐surgical periodontal therapy on circulating levels of the systemic inflammation‐associated biomarkers orosomucoid (ORM), high‐sensitivity C‐reactive protein (hsCRP), chemerin, and retinol‐binding protein 4 (RBP4) in overweight or normal‐weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO‐trial (ClinicalTrials.gov NCT00707369). The per‐protocol collective provided untreated periodontitis patients with high (≥28 kg/m2) or moderate (21–24 kg/m2) BMI. Out of the per‐protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal‐weight patients. Patients received non‐surgical periodontal therapy and maintenance at 3‐month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5‐month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal‐weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non‐surgical periodontal therapy reduced systemically elevated inflammation‐associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal‐weight patients.

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Metadaten
Author: Johannes Matern, Raphael Koch, Astrid Petersmann, Thomas Kocher, Peter Eickholz, Katrin Lorenz, Ti‐Sun Kim, Jörg Meyle, Doğan Kaner, Ulrich Schlagenhauf, Martina Gravemeier, Inga Harks, Benjamin Ehmke
URN:urn:nbn:de:gbv:9-opus-40875
DOI:https://doi.org/10.1111/jcpe.13288
Parent Title (English):Journal of Clinical Periodontology
Document Type:Article
Language:English
Date of first Publication:2020/06/15
Release Date:2020/12/01
Tag:chemerin; orosomucoid; overweight; periodontitis; retinol‐binding protein 4
GND Keyword:-
Volume:47
Issue:7
First Page:842
Last Page:850
Faculties:Universitätsmedizin / Institut für Klinische Chemie und Laboratoriumsmedizin
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell