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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-45184

Alexithymia Is Associated with Altered Cortical Thickness Networks in the General Population

  • Background: Alexithymia is a personality trait characterized by difficulties in identifying and describing emotions and associated with various psychiatric disorders. Neuroimaging studies found evidence for morphological and functional brain alterations in alexithymic subjects. However, the neurobiological mechanisms underlying alexithymia remain incompletely understood. Methods: We study the association of alexithymia with cortical correlation networks in a large community-dwelling sample of the Study of Health in Pomerania. Our analysis includes data of n = 2,199 individuals (49.4% females, age = 52.1 ± 13.6 years) which were divided into a low and high alexithymic group by a median split of the Toronto Alexithymia Scale. Cortical correlation networks were constructed based on the mean thicknesses of 68 regions, and differences in centralities were investigated. Results: We found a significantly increased centrality of the right paracentral lobule in the high alexithymia network after correction for multiple testing. Several other regions with motoric and sensory functions showed altered centrality on a nominally significant level. Conclusions: Finding increased centrality of the paracentral lobule, a brain area with sensory as well as motoric features and involvement in bowel and bladder voiding, may contribute to explain the association of alexithymia with functional somatic disorders and chronic pain syndromes.

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Metadaten
Author: Jan Terock, Stefan Frenzel, Katharina Wittfeld, Johanna Klinger-König, Deborah Janowitz, Robin Bülow, Norbert Hosten, Henry Völzke, Hans Jörgen Grabe
URN:urn:nbn:de:gbv:9-opus-45184
DOI:https://doi.org/10.1159/000504983
ISSN:0302-282X
ISSN:1423-0224
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/32146473
Parent Title (English):Neuropsychobiology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2020/03/06
Release Date:2021/06/21
Tag:Alexithymia; Centrality; Connectivity; Correlation networks; Cortex; General population
GND Keyword:-
Volume:79
Issue:3
First Page:233
Last Page:244
Faculties:Universitätsmedizin / Klinik für Psychiatrie und Psychotherapie
Licence (German):License LogoUrheberrechtlich geschützt