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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31051

Mucositis after Reduced Intensity Conditioning and Allogeneic Stem Cell Transplantation

  • Background: Therapyrelated mucositis is associated with considerable morbidity. This complication following allogeneic stem cell therapy (alloSCT) is less severe after reduced intense conditioning (RIC); however, even here it may be serious. Methods: 52 patients (male: n = 35 (67%), female: n = 17 (33%)) at a median age of 62 years (35–73 years) underwent alloSCT after RIC. Conditioning was either total body irradiation (TBI)<sub>2Gy</sub>/±fludarabine (n = 33, 63.5%) or chemotherapy based. Graftversushost disease (GvHD) prophylaxis was carried out with cyclosporine A ± mycophenolate mofetil (MMF). 45 patients (87%) received shortcourse methotrexate (MTX). Mucositis was graded according to the Bearman and the World Health Organisation (WHO) scale. A variety of parameters were correlated with mucositis. Results: The Bearman and WHO scales showed excellent correlation. Mucositis was significantly more severe after chemotherapybased conditioning compared to conditioning with TBI<sub>2Gy</sub>/±fludarabine (p < 0.002) as well as in cases with an increase in creatinine levels above the upper normal value (UNV) on day +1 after SCT (p < 0.05). Furthermore, the severity correlated with time to engraftment of leucocytes (correlation coefficient (cc) = 0.26, p < 0.02) and thrombocytes (cc = 0.38, p < 0.001). Conclusions: The conditioning regimen and increased creatinine levels at day +1 were identified as factors predicting the severity of mucositis after RICSCT. Creatinine levels on day +1 after SCT may help identify patients at risk for severe mucositis in the further course of transplantation.

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Metadaten
Author: Christoph Busemann, Hanna Wilfert, Thomas Neumann, Thomas Kiefer, Gottfried Dölken, William H. Krüger
URN:urn:nbn:de:gbv:9-opus-31051
URL:http://www.karger.com/onk
DOI:https://doi.org/10.1159/000332131
ISSN:2296-5270
ISSN:2296-5262
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/21985850
Parent Title (English):Oncology Research and Treatment
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2011/09/16
Release Date:2020/09/29
Tag:Allogeneic stem cell transplantation; Conditioning therapy; Mucositis; Toxicity; Transplantrelated morbidity
GND Keyword:-
Volume:34
Issue:10
First Page:518
Last Page:524
Faculties:Universitätsmedizin
Licence (German):License LogoUrheberrechtlich geschützt