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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-30785

Residual Antimicrobial Effect of Chlorhexidine Digluconate and Octenidine Dihydrochloride on Reconstructed Human Epidermis

  • The objective of the present investigation was to examine the residual antimicrobial activity after a topical exposure of reconstructed human epidermis (RHE) to equimolar solutions of either chlorhexidine digluconate (CHG, 0.144% w/v) or octenidine dihydrochloride (OCT, 0.1% w/v) for 15 min. RHE-associated antiseptic agents were more effective on Staphylococcus aureus than on Pseudomonas aeruginosa. S. aureus was not detected after 24 h of contact, which demonstrated a microbicidal efficacy of greater than 5-log<sub>10</sub> reduction. In contrast, P. aeruginosa was reduced by approximately 2 log<sub>10</sub> at the same incubation time, which parallels the growth of the initial inoculum. This result could be interpreted either as a microbiostatic effect or as an adherence of P. aeruginosa to a low positively charged surface. Small amounts of CHG and OCT can penetrate the stratum corneum. Using these antiseptic agents, the viability of keratinocytes was reduced to 65-75% of that of the untreated RHE control following 24 h incubation in the presence of test microorganisms. With consideration of antimicrobial activity and cytotoxic effect, OCT corresponds better to a biocompatible antiseptic agent than CHG.

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Author: G. Müller, J. Langer, J. Siebert, A. Kramer
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=23887383
Parent Title (English):Skin Pharmacology and Physiology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Date of first Publication:2013/07/24
Release Date:2020/09/29
Tag:Antiseptics; Chlorhexidine digluconate; Octenidine dihydrochloride; Reconstructed human epidermis; Residual antimicrobial effect
GND Keyword:-
First Page:1
Last Page:8
Faculties:Universitätsmedizin / Institut für Hygiene und Umweltmedizin
Licence (German):License LogoUrheberrechtlich geschützt