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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-35954

Is BK Virus-Associated Cystitis a Generalized Epithelial Disease?

  • BK polyomavirus-associated haemorrhagic cystitis (BKHC) is a complication after allogeneic stem cell transplantation, which can occur in 5–60% of the cases. BK viruria alone can also occur in up to 100%. BKHC can lead to severe morbidity in stem cell-transplanted patients, but data about this disease is limited. Consequently, we conducted a prospective unicentric non-interventional trial on BKHC as well as BK viruria after first adult allogeneic stem cell transplantation with a follow-up time of 1 year after inpatient treatment. Between November 2013 and December 2015, we were able to include 40 adult patients with a mean age of 52.8 years. Twenty-seven (67.5%) of these patients were male and 13 (32.5%) were female. Acute myeloid leukaemia was the most frequent underlying disease (n = 15; 37.5%). Only 1 patient developed BKHC during inpatient treatment (n = 1; 2.5%), but BK viruria was frequent (n = 11; 27.5%) during inpatient treatment as well as in the follow-up time (n = 14; 35%). Interestingly, BK viruria was significantly associated with mucositis (p = 0.038) and number of transfused platelet concentrates (p = 0.001). This unexpected association will be discussed and needs further investigation.

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Metadaten
Author: Laila Schneidewind, Thomas Neumann, Kathrin Zimmermann, Martin Weigel, Christian Andreas Schmidt, William Krüger
URN:urn:nbn:de:gbv:9-opus-35954
DOI:https://doi.org/10.1159/000494748
ISSN:0001-5792
ISSN:1421-9662
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30605908
Parent Title (English):Acta Haematologica
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2019/01/03
Release Date:2022/04/08
Tag:Allogeneic stem cell transplantation; BK virus; Haemorrhagic cystitis
GND Keyword:-
Volume:141
Issue:2
First Page:65
Last Page:67
Faculties:Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin
Licence (German):License LogoUrheberrechtlich geschützt