Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-108522
Association of plasma chemerin with all-cause and disease-specific mortality – results from a population-based study
- Background and objectives Various cross-sectional studies have observed an association between high circulating concentrations of the adipokine chemerin and an unfavorable metabolic profile. However, the prognostic value of chemerin for the risk of associated diseases and mortality was examined only in a few studies mostly using small and highly selected patient populations. We aimed to analyze the association between plasma chemerin concentrations and all-cause as well as cause-specific mortality in the general population. Study design and methods From the Study of Health in Pomerania (SHIP), participants of two independent cohorts (SHIP-START-1 [n = 3037], SHIP-TREND-0 [n = 4193]) were followed up for 15 and 9 years (median), respectively. The association between plasma chemerin and all-cause mortality was analyzed using multivariable Cox proportional hazard regression models. Additionally, cause-specific hazards for cardiovascular disease (CVD) and cancer mortality were modeled considering competing events. Results A total number of 507 and 208 deaths occurred during follow-up in SHIP-START-1 and SHIP-TREND-0, respectively. Multivariable regression analyses revealed a significant association between high plasma chemerin concentrations and greater overall mortality that was independent of major confounders. Each 30 ng/mL increase in chemerin was associated with a 17% higher risk of all-cause mortality (95%-confidence interval: 1.10–1.26). Cause-specific analyses further showed that the chemerin concentration was significantly associated with cancer mortality but not with CVD mortality. Conclusion The present study detected a positive association between plasma chemerin concentrations and all-cause mortality in a large population-based study sample. Cause-specific analyses have shown that chemerin is likely to play a decisive role in cancer-related deaths. However, a direct association with cardiovascular mortality could not be established.
Author: | Katharina Noppes, Stefan Groß, Anke Hannemann, Marcello Ricardo Paulista Markus, Martin Bahls, Henry VölzkeORCiD, Marcus DörrORCiD, Matthias NauckORCiD, Nele Friedrich, Stephanie Zylla |
---|---|
URN: | urn:nbn:de:gbv:9-opus-108522 |
DOI: | https://doi.org/10.1038/s41366-023-01342-0 |
ISSN: | 1476-5497 |
Parent Title (English): | International Journal of Obesity |
Publisher: | Nature Publishing Group |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/07/25 |
Date of first Publication: | 2023/10/01 |
Release Date: | 2024/03/11 |
Volume: | 47 |
Issue: | 10 |
First Page: | 956 |
Last Page: | 962 |
Faculties: | Universitätsmedizin / Institut für Klinische Chemie und Laboratoriumsmedizin |
Collections: | weitere DFG-förderfähige Artikel |
Licence (German): | Creative Commons - Namensnennung 4.0 International |