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No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study
- Background Observational and in-vivo research suggested a bidirectional relationship between depression and periodontitis. We estimated the genetic correlation and examined directionality of causation. Methods The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation. Results LDSC observed only weak genetic correlation (rg = 0.06, P-Value = 0.619) between depression and periodontitis. Analysis of local genetic correlation using ρ-HESS did not reveal loci of significant local genetic covariance. LHC-MR, CAUSE and conventional MR models provided no support for bidirectional causation between depression and periodontitis, with odds ratios ranging from 1.00 to 1.06 in either direction. Conclusions Results do not support shared heritability or a causal connection between depression and periodontitis.
Author: | Michael Nolde, Birte Holtfreter, Thomas Kocher, Zoheir Alayash, Stefan Lars Reckelkamm, Benjamin Ehmke, Hansjörg Baurecht, Sebastian-Edgar Baumeister |
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URN: | urn:nbn:de:gbv:9-opus-64072 |
DOI: | https://doi.org/10.3389/fimmu.2022.918404 |
ISSN: | 1664-3224 |
Parent Title (English): | Frontiers in Immunology |
Publisher: | Frontiers Media S.A. |
Place of publication: | Lausanne |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2022/07/22 |
Release Date: | 2022/11/25 |
Tag: | depression; genetic correlation; genetic correlation analysis; mendelian randomization analysis; periodontitis |
GND Keyword: | - |
Volume: | 13 |
Article Number: | 918404 |
Page Number: | 9 |
Faculties: | Universitätsmedizin / Poliklinik für Kieferorthopädie, Präventive Zahnmedizin und Kinderzahnheilkunde |
Licence (German): | Creative Commons - Namensnennung |