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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-47089

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment

  • A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.

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Author: Nikolai Siemens, Sonja Oehmcke-Hecht, Jörn Hoßmann, Sebastian B. Skorka, Roel H.T. Nijhuis, Corinne Ruppen, Steinar Skrede, Manfred Rohde, Daniel Schultz, Michael Lalk, Andreas Itzek, Dietmar H. Pieper, Christiaan J. van den Bout, Eric C.J. Claas, Ed J. Kuijper, Robert Mauritz, Parham Sendi, Herman F. Wunderink, Anna Norrby-Teglund
URN:urn:nbn:de:gbv:9-opus-47089
DOI:https://doi.org/10.1159/000504002
ISSN:1662-811X
ISSN:1662-8128
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=31743913
Parent Title (English):Journal of Innate Immunity
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2019/11/19
Release Date:2021/07/27
Tag:Coagulation; Group B streptococcus; Hemolysis; Inflammation; Pigment
GND Keyword:-
Volume:12
Issue:4
First Page:291
Last Page:303
Faculties:Mathematisch-Naturwissenschaftliche Fakultät / Abteilung für Mikrobiologie und Molekularbiologie
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung