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Associations of spleen volume with markers of blood count and lipid profile in a large population-based study
- Background: The aim of our study was to investigate associations of spleen volume with blood count markers and lipid profile in the general population. Materials & methods: Cross-sectional data from 1,106 individuals aged 30–90 years from the population-based Study of Health in Pomerania (SHIP-START-2) were analyzed. Blood count markers included red blood cell (RBC) counts, hemoglobin, platelet count, and white blood cell (WBC) counts. Lipid profile included total-cholesterol, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) as well as triglycerides. Linear regression models adjusted for age, sex, body height, and weight were used to associate standardized spleen volume with blood counts and lipid profile markers. Results: Spleen volume was positively associated with RBC (β = 0.05; 95% confidence interval [CI] = 0.03 to 0.08) and hemoglobin (β = 0.05; 95% CI = 0.01 to 0.09) but inversely with platelet count (β = −16.3; 95% CI = –20.5 to −12.1) and WBC (β = −0.25; 95% CI = −0.37 to −0.14). Furthermore, spleen volume showed inverse associations with total cholesterol (β = −0.17; 95% CI = −0.24 to −0.09), HDL-C (β = −0.08; 95% CI = −0.10 to −0.05), and LDL-C (β = −0.12; 95% CI = −0.17 to −0.06). There was no significant association of spleen volume with triglycerides. Conclusion: Our study showed that the spleen volume is associated with markers of the blood count and lipid profile in the general population.
Author: | Muhammad Naeem, Till Ittermann, Marcello Ricardo Paulista Markus, Mohammed Farah Mahmoud Mousa, Laura von Heder, Robin Bülow, Marcus Dörr, Matthias NauckORCiD, Ali Aghdassi, Florian H. Heidel, Henry VölzkeORCiD |
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URN: | urn:nbn:de:gbv:9-opus-105920 |
DOI: | https://doi.org/10.48101/ujms.v128.9785 |
ISSN: | 2000-1967 |
Parent Title (English): | Upsala Journal of Medical Sciences |
Publisher: | Upsala Medical Society |
Place of publication: | Uppsala |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2023/09/15 |
Release Date: | 2024/02/01 |
Tag: | MRI; blood count; lipid profile; spleen volume |
Volume: | 128 |
Article Number: | e9785 |
Page Number: | 6 |
Faculties: | Universitätsmedizin / Institut für Community Medicine |
Collections: | Artikel aus DFG-gefördertem Publikationsfonds |
Licence (German): | Creative Commons - Namensnennung |