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Azide‐Modified Nucleosides as Versatile Tools for Bioorthogonal Labeling and Functionalization
- Abstract Azide‐modified nucleosides are important building blocks for RNA and DNA functionalization by click chemistry based on azide‐alkyne cycloaddition. This has put demand on synthetic chemistry to develop approaches for the preparation of azide‐modified nucleoside derivatives. We review here the available methods for the synthesis of various nucleosides decorated with azido groups at the sugar residue or nucleobase, their incorporation into oligonucleotides and cellular RNAs, and their application in azide‐alkyne cycloadditions for labelling and functionalization.
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| Author: | Frederik Müggenburg, Sabine Müller |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-63088 |
| DOI: | https://doi.org/10.1002/tcr.202100322 |
| Parent Title (English): | The Chemical Record |
| Publisher: | Wiley |
| Place of publication: | Hoboken, NJ |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/05/13 |
| Release Date: | 2022/11/29 |
| Tag: | Azides; Click chemistry; Oligonucleotides; Synthetic methods |
| Volume: | 22 |
| Issue: | 5 |
| Article Number: | e202100322 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie |
| Collections: | weitere DFG-förderfähige Artikel |
| Licence (German): |  Creative Commons - Namensnennung |