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Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-31112

Clinically Relevant Depressive Symptoms in Young Stroke Patients - Results of the sifap1 Study

  • Background: Although post-stroke depression is widely recognized, less is known about depressive symptoms in the acute stage of stroke and especially in young stroke patients. We thus investigated depressive symptoms and their determinants in such a cohort. Methods: The Stroke in Young Fabry Patients study (sifap1) prospectively recruited a large multinational European cohort (n = 5,023) of patients with a cerebrovascular event aged 18-55. For assessing clinically relevant depressive symptoms (CRDS, defined by a BDI-score ≥18) the self-reporting Beck Depression Inventory (BDI) was obtained on inclusion in the study. Associations with baseline parameters, stroke severity (National Institutes of Health Stroke Scale, NIHSS), and brain MRI findings were analyzed. Results: From the 2007 patients with BDI documentation, 202 (10.1%) had CRDS. CRDS were observed more frequently in women (12.6 vs. 8.2% in men, p < 0.001). Patients with CRDS more often had arterial hypertension, diabetes mellitus, and hyperlipidemia than patients without CRDS (hypertension: 58.0 vs. 47.1%, p = 0.017; diabetes mellitus: 17.9 vs. 8.9%, p < 0.001; hyperlipidemia: 40.5 vs. 32.3%, p = 0.012). In the subgroup of patients with ischemic stroke or TIA (n = 1,832) no significant associations between CRDS and cerebral MRI findings such as the presence of acute infarcts (68.1 vs. 65.8%, p = 0.666), old infarctions (63.4 vs. 62.1%, p = 0.725) or white matter hyper-intensities (51.6 vs. 53.7%, p = 0.520) were found. Conclusion: Depressive symptoms were present in 10.1% of young stroke patients in the acute phase, and were related to risk factors but not to imaging findings.

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Author: Christian Tanislav, Peter Kropp, Ulrike Grittner, Martin Holzhausen, Franz Fazekas, Gerhard Jan Jungehülsing, Turgut Tatlisumak, Bettina von Sarnowski, Jukka Putaala, Roman Huber, Vincent Thijs, Reinhold Schmidt, Manfred Kaps, Christian Enzinger, Martin Dichgans, Bo Norrving, Arndt Rolfs
URN:urn:nbn:de:gbv:9-opus-31112
URL:http://www.karger.com/ned
DOI:https://doi.org/10.1159/000371389
ISSN:0251-5350
ISSN:1423-0208
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/25659436
Parent Title (English):Neuroepidemiology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2015/01/31
Release Date:2020/09/29
Tag:Acute cerebral ischemia; Depression; Risk factors; Young stroke; sifap1
GND Keyword:-
Volume:44
Issue:1
First Page:30
Last Page:38
Faculties:Universitätsmedizin / Klinik und Poliklinik für Neurologie
Licence (German):License LogoUrheberrechtlich geschützt