Bitte verwenden Sie diesen Link, wenn Sie dieses Dokument zitieren oder verlinken wollen: https://nbn-resolving.org/urn:nbn:de:gbv:9-opus-65344
The Proteasome Activator PA200/PSME4: An Emerging New Player in Health and Disease
- Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases. Several proteasome inhibitors are approved for treating hematological cancers. However, their side effects impede their efficacy and broader therapeutic applications. Therefore, understanding the biology of the different proteasome complexes present in the cell is crucial for developing tailor-made inhibitors against specific proteasome complexes. Here, we will discuss the structure, biology, and function of the alternative Proteasome Activator 200 (PA200), also known as PSME4, and summarize the current evidence for its dysregulation in different human diseases. We hereby aim to stimulate research on this enigmatic proteasome regulator that has the potential to serve as a therapeutic target in cancer.
Download full text files
Additional Services
Statistics
| Author: | Ayse Seda Yazgili, Frédéric Ebstein, Silke Meiners |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-65344 |
| DOI: | https://doi.org/10.3390/biom12081150 |
| ISSN: | 2218-273X |
| Parent Title (English): | Biomolecules |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Editor: | Maria E. Gaczyńska |
| Document Type: | Article |
| Language: | English |
| Date of first Publication: | 2022/08/20 |
| Release Date: | 2022/11/21 |
| Tag: | PA200; PSME4; proteasome |
| GND Keyword: | - |
| Volume: | 12 |
| Issue: | 8 |
| Page Number: | 14 |
| Faculties: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Mikrobiologie - Abteilung für Genetik & Biochemie |
| Licence (German): |  Creative Commons - Namensnennung |