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Generation of a human induced pluripotent stem cell line (UMGACBi001-A) from urine cells of a chronic kidney disease patient with hypertension, diabetic nephropathy and acute sepsis
- Chronic kidney disease is a major public health burden associated with a drastically reduced quality of living and life span that lacks suitable, individualized therapeutic strategies. Here we present a human induced pluripotent stem cell line (iPSC, UMGACBi001-A) reprogrammed from urine cells of an acute septic dialysis patient suffering from chronic kidney disease using non-integrating administration of RNAs. The generated iPSCs were positively characterized for typical morphology, pluripotency marker expression, directed differentiation potential, non-contamination, chromosomal consistency and donor identity. This iPSC-line can be a useful source for in vitro disease modelling and individualized therapeutic approaches.
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| Author: | Tim Lange, Sophia-Marie Bach, Thor-Magnus Koppe, Anja Klann, Anja Weise, Robin Alexander Pilz, Norina Loth, Sabrina von Rheinbaben, Sylvia Stracke, Nicole Endlich |
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| URN: | urn:nbn:de:gbv:9-opus-109072 |
| DOI: | https://doi.org/10.1016/j.scr.2023.103224 |
| ISSN: | 1876-7753 |
| Parent Title (English): | Stem Cell Research |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2023/10/20 |
| Date of first Publication: | 2023/12/01 |
| Release Date: | 2024/03/22 |
| Volume: | 73 |
| Article Number: | 103224 |
| Page Number: | 4 |
| Faculties: | Universitätsmedizin / Institut für Anatomie und Zellbiologie |
| Collections: | weitere DFG-förderfähige Artikel |
| Licence (German): |  Creative Commons - Namensnennung 4.0 International |